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Persistence of SARS-CoV-2: a new paradigm of COVID-19 management
L B Alhusseini1, L T Yassen2, E Kouhsari3,4
1Department of Ecology, College of Science, Kufa University, Najaf, Iraq.
Insights
Patients recovered from Coronavirus disease 2019 (COVID-19) require careful follow-up. This study examines the persistence of SARS-CoV-2 and the potential for reinfection in COVID-19 survivors.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, emerged in Wuhan, China.
- Previous studies primarily focused on epidemiological, clinical, and radiological aspects of COVID-19.
- Gaps remain in understanding viral transmission, clinical progression, and immunity after infection.
Purpose of the Study:
- To investigate the evidence of SARS-CoV-2 persistence in recovered patients.
- To explore the possibility of SARS-CoV-2 reinfection in individuals who have survived the initial illness.
- To address concerns regarding viral shedding and immunity in COVID-19 survivors.
Main Methods:
- Review of existing literature and case reports on SARS-CoV-2 persistence.
- Analysis of studies reporting positive SARS-CoV-2 tests in recovered patients post-discharge.
- Examination of evidence related to potential reinfection in COVID-19 survivors.
Main Results:
- Reports indicate SARS-CoV-2 persistence in recovered patients, with positive tests observed after hospital discharge in China, Japan, and South Korea.
- Evidence suggests that SARS-CoV-2 reinfection may occur in individuals who have previously had the virus.
- The implications of viral persistence and potential reinfection for immunity remain under-studied.
Conclusions:
- Further rigorous studies with larger sample sizes are needed to confirm findings on SARS-CoV-2 persistence and reinfection.
- Understanding viral persistence and immunity is crucial for managing the long-term impact of COVID-19.
- Close monitoring and follow-up of recovered COVID-19 patients are essential.
Abstract:
Full attention must be given to the follow-up of patients recovered from Coronavirus disease 2019, which developed in Wuhan, China in December 2019. Among the most serious issues since the emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 has been whether those who had it can experience a second episode of infection and what that implies for immunity. The earlier studies on COVID-19 disease focused primarily on the epidemiological, clinical, and radiological characteristics of patients with CO-VID-19. However, conclusions of these studies still require to be warranted by more careful design, larger sample size and statistically well structured studies. COVID-19 is an under-studied infection, and several aspects of viral transmission and clinical progress remain at present unclear. There is a concern about the persistence of SARS-CoV-2 on various surfaces and in the respiratory system of patients who have survi-ved. One of the most concerning issues since the emergence of the SARS-CoV-2 is persistence in patients and whether patients can be re-infected. After hospital discharge, recovered patients were reported to have positive SARS-CoV-2 test in China, Japan, and South Korea. In addition to the persistence of the virus, SARS-CoV-2 re-infection may occur in survivors. In this paper, we focused on the evidence of persistence and re-infection of SARS-CoV-2.
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