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Updated: Nov 21, 2025

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses
Published on: March 8, 2024
What Is a Cytokine Storm and Should It Matter to Me?
Jennifer Simkin1, Tierra Strange, Nicholas Leblanc
1From the Department of Orthopaedic Surgery, Louisiana State University Health Science Center, New Orleans, LA.
Abstract:
The recent COVID-19 pandemic has brought attention to cytokines and the phenomenon of cytokine storm into mainstream discussions. In this disease specifically, a cytokine storm overwhelming immune response contributes to the pathophysiology and mortality of the COVID-19 infection. Analogous perturbed immune reactions are experienced in polytrauma patients, compromising local tissue healing while threatening multiple organ systems. The expanding field of osteoimmunology should contribute to the orthopaedic community's understanding of how the immune system response, whether normal or pathologic, affects the whole body outcome of our patients.
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