Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Author Correction: Photothermal effects control ultrafast charge transport in titanium carbide MXenes.

Nature communications·2026

Same author

Water-Mediated Ion Selectivity in 2D MXene Channels.

Journal of the American Chemical Society·2026

Same author

Sodium-Ion-Assisted Minimally Intensive Layer Delamination of Ti-Based MXenes: Implications for Biomedical Applications.

ACS applied nano materials·2026

Same author

Large-Scale Integration of Experimental and Computational Data for 2D Materials.

ACS nano·2026

Same author

MXene-Modified Fiber-Based Electronic Tongue for Sensitive Detection of Antibiotic Residues in Milk.

ACS omega·2026

Same author

Critical Assessment of Intrinsic Antibacterial Properties and Photothermal Therapy Potential of MXene Nanosheets.

ACS applied nano materials·2026

Search research articles

Related Experiment Video

Updated: Nov 21, 2025

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

Moderating cellular inflammation using 2-dimensional titanium carbide MXene and graphene variants.

Tochukwu Ozulumba¹, Ganesh Ingavle², Yury Gogotsi³

¹School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, BN2 4GJ, UK. s.sandeman@brighton.ac.uk and Department of Chemistry, University of Virginia, Charlottesville, VA 22904, USA.

Biomaterials Science

|January 14, 2021

Summary

Two-dimensional nanomaterials like graphene and MXene effectively remove harmful biological toxins and reduce inflammatory cytokines. These materials show promise for use in blood-contacting medical devices to improve patient outcomes.

More Related Videos

Graphene Coatings for Biomedical Implants

Graphene Coatings for Biomedical Implants

Published on: March 1, 2013

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Related Experiment Videos

Last Updated: Nov 21, 2025

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

Graphene Coatings for Biomedical Implants

Graphene Coatings for Biomedical Implants

Published on: March 1, 2013

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Area of Science:

Biomedical Engineering
Materials Science
Toxicology

Background:

Controlling biological toxins is a major health challenge.
Graphene and MXene nanomaterials offer large surface areas for toxin adsorption.
Their interactions with biological systems require further investigation.

Purpose of the Study:

To compare titanium carbide MXene (Ti3C2Tx) and graphene variants for their biological interactions.
To assess the impact of nanomaterial physical properties on cellular inflammatory response.
To evaluate their potential for adsorptive remediation of biological toxins.

Main Methods:

Comparison of multilayered and delaminated Ti3C2Tx with graphene variants.
Assessment of cellular inflammatory response to endotoxin stimulus.
Evaluation of antibacterial activity and cytokine production reduction.

Main Results:

No significant impact on cell metabolism, inflammatory pathways, or cell death observed.
No significant increase in blood cell activation or haemolysis.
Silver nanoparticle-modified graphene oxide (GO-Ag) showed antibacterial activity.
All tested nanomaterials significantly reduced endotoxin-induced cytokine production (IL-8, IL-6, TNF-α).

Conclusions:

Nanomaterials show potential as adsorbents in blood-contacting medical devices.
They can remove inflammatory cytokines linked to adverse outcomes in severe infections.
Further research into their physiological interactions is warranted.