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Project ACTIVE: a Randomized Controlled Trial of Personalized and Patient-Centered Preventive Care in an Urban

Melanie Applegate¹, Ebony Scott², Glen B Taksler³

¹New York University Langone Health, 462 1st Avenue, Desk 2D, New York, NY, 10016, USA. Melanie.A.Applegate@gmail.com.

Journal of General Internal Medicine

|January 14, 2021

Abstract

Background:

Evidence-based preventive care in the USA is underutilized, diminishing population health and worsening health disparities. We developed Project ACTIVE, a program to improve adherence with preventive care goals through personalized and patient-centered care.

Objective:

To determine whether Project ACTIVE improved utilization of preventive care and/or estimated life expectancy compared to usual care.

Design:

Single-site randomized controlled trial.

Participants:

Cluster-randomized 140 English or Spanish speaking adult patients in primary care with at least one of twelve unfulfilled preventive care goals based on USPSTF grade A and B recommendations.

Intervention:

Project ACTIVE employs a validated mathematical model to predict and rank individualized estimates of health benefit that would arise from improved adherence to different preventive care guidelines. Clinical staff engaged the participant in a shared medical decision-making (SMD) process to identify highest priority unfulfilled clinical goals, and health coaching staff engaged the participant to develop and monitor action steps to reach those goals.

Main Measures:

Change in number of unfulfilled preventive care goals from USPSTF grade A and B recommendations and change in overall gain in estimated life expectancy.

Key Results:

In an intent-to-treat analysis, Project ACTIVE increased the average number of fulfilled preventive care goals out of 12 by 0.68 in the intervention arm compared with 0.15 in the control arm (mean difference [95% CI] 0.53 [0.19-0.86]), yielding a gain in estimated life expectancy of 8.8 months (3.8, 14.2). In a per-protocol analysis, Project ACTIVE increased fulfilled preventive care goals by 0.80 in the intervention arm compared with 0.16 in the control arm (mean difference [95% CI], 0.65 [0.25-1.04]), yielding a gain in estimated life expectancy of 13.7 months (6.2, 21.2). Among the 12 preventive care goals, more improvement occurred for alcohol use, hypertension, hyperlipidemia, depression, and smoking.

Conclusions:

Project ACTIVE improved unfulfilled preventive care goals and improved estimated life expectancy.

Clinical Trial Registration Number:

NCT04211883.

Keywords:

patient-centered care personalization prevention preventive care

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