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Interdigestive motility and motilin in hypophysectomized patients
T L Peeters1, J Janssens, C Plets
1Dept. of Medical Research, Catholic University of Leuven, Belgium.
Scandinavian Journal of Gastroenterology
|January 1, 1988
Summary
The anterior pituitary (adenohypophysis) does not regulate motilin levels or interdigestive motility. Studies in hypophysectomized patients show normal motilin fluctuations and cyclic intestinal activity.
Area of Science:
- Gastroenterology
- Endocrinology
- Neurogastroenterology
Background:
- Motilin is a key hormone regulating gastrointestinal motility.
- The role of the anterior pituitary in motilin regulation and interdigestive motility is not fully understood.
Purpose of the Study:
- To investigate the role of the adenohypophysis in regulating basal motilin levels.
- To examine the correlation between motilin fluctuations and interdigestive intestinal motor activity in hypophysectomized patients.
Main Methods:
- Studied five hypophysectomized patients with anterior lobe resection.
- Monitored basal motilin levels and correlated them with intestinal motor activity, specifically activity fronts (AF).
- Compared findings to previously reported data from normal volunteers.
Main Results:
- Hypophysectomized patients exhibited a cyclic pattern of intestinal motor activity similar to normal individuals.
- The mean interval between activity fronts (115 min) was not significantly different from normal.
- Motilin levels remained within the normal range and fluctuated in correlation with activity fronts, with changes comparable to those in normal volunteers.
Conclusions:
- The adenohypophysis is not involved in the regulation of basal motilin levels in humans.
- The adenohypophysis does not play a role in the regulation of interdigestive intestinal motility.