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Updated: Nov 21, 2025

Multi-Fiber Photometry to Record Neural Activity in Freely-Moving Animals
Published on: October 20, 2019
A selected review of recent advances in the study of neuronal circuits using fiber photometry
Yuanmo Wang1, Emily M DeMarco2, Lisa Sophia Witzel3
1Department of Chemistry and Chemical Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.
Abstract:
To understand the correlation between animal behaviors and the underlying neuronal circuits, it is important to monitor and record neurotransmission in the brain of freely moving animals. With the development of fiber photometry, based on genetically encoded biosensors, and novel electrochemical biosensors, it is possible to measure some key neuronal transmission events specific to cell types or neurotransmitters of interest with high temporospatial resolution. This review discusses the recent advances and achievements of these two techniques in the study of neurotransmission in animal models and how they can be used to complement other techniques in the neuroscientist's toolbox.

