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Published on: October 28, 2015
Amphiphilic Near-Infrared Conjugated Polymer for Photothermal and Chemo Combination Therapy
Jingke Yao1,2, Shusen Kang1,2, Jian Zhang1,2
1State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Remin Street 5625, Changchun 130022, P. R. China.
Abstract:
Amphiphilic conjugated polymer was designed and utilized as nanocarriers without further general encapsulation using PEGylated materials for photothermal therapy (PTT) and chemotherapy. These nanocarriers have maximum absorption in ideal phototherapeutic window between 800 and 850 nm and excellent photothermal conversion efficiency of 76% at 808 nm. It provides the simultaneous therapy of chemotherapy and PTT with the monitoring of photoacoustic imaging. After combined therapy via tail vein injection, complete remission and no recurrence of tumors can be observed over a course of 20 days, indicating these amphiphilic NPs has great potential for NIR photoacoustic imaging-guided photothermal and chemo combined therapy.
