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Supramolecular Hydrogel Inspired from DNA Structures Mimics Peroxidase Activity.

Tanima Bhattacharyya1, Y Pavan Kumar1, Jyotirmayee Dash1

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Summary
This summary is machine-generated.

New supramolecular hydrogels formed from guanosine and boronic acids exhibit enzyme-like peroxidase activity. These G-quartet hydrogels can also act as molecular logic gates for sensing toxic lead (Pb2+) ions.

Keywords:
DNAzymeenzyme mimicguanosinelogic operationsupramolecular chemistry

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Biomimetic Chemistry

Background:

  • G-quartet structures are nucleic acid secondary structures with diverse biological roles.
  • Supramolecular hydrogels offer versatile platforms for developing functional materials.
  • Enzyme-mimicking catalysts are crucial for various chemical and biomedical applications.

Purpose of the Study:

  • To synthesize novel supramolecular hydrogels from guanosine and boronic acids.
  • To investigate the G-quartet-like self-assembly and properties of these hydrogels.
  • To explore the potential of these hydrogels in biomimetic catalysis and sensing.

Main Methods:

  • Hydrogel formation using guanosine, boronic acids, and stabilizing cations (K+, Pb2+).
  • Characterization of hydrogel self-assembly and structure.
  • Assay of peroxidase-like activity using iron(III)-hemin and 3,3',5,5'-tetramethylbenzidine (TMB).
  • Development of a molecular logic gate for lead ion sensing based on conformational changes.

Main Results:

  • Successful preparation of supramolecular hydrogels from guanosine and boronic acids.
  • Demonstration of G-quartet-like self-assembly driven by guanosine boronate esters.
  • Observation of peroxidase-like activity in K+-stabilized hydrogels, catalyzing TMB oxidation.
  • Conformational switching of G-quartet assemblies induced by K+ and Pb2+ ions.
  • Successful implementation of a molecular logic gate for sensing toxic Pb2+ ions.

Conclusions:

  • Guano-sine-based supramolecular hydrogels can be formed and exhibit G-quartet-like assemblies.
  • These hydrogels possess biomimetic peroxidase activity when complexed with iron(III)-hemin.
  • The cation-dependent conformational changes allow for the development of ion-responsive molecular logic gates.
  • This work presents a novel approach for creating functional hydrogels for catalysis and sensing applications.