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Development and Characterization of Gallium-Doped Bioactive Glasses for Potential Bone Cancer Applications
Karan S Rana1, Lucas Pereira de Souza1, Mark A Isaacs1
1Aston Institute of Materials Research, School of Engineering & Applied Science and Aston Research Centre for Healthy Ageing, University of Aston, Birmingham B4 7ET, United Kingdom.
Abstract:
In this study, we have developed a series of novel gallium oxide doped bioactive glasses to specifically target osteosarcoma cells while aiding new bone formation. The results show that osteosarcoma (Saos-2) cell death is induced through the addition of gallium oxide. Relative to the gallium-free control glass (0% Ga) glasses containing 1, 2, and 3% Ga decreased Saos-2 cell viability in a dose dependent manner. After 72 h in media preconditioned with 3% Ga Saos-2 cell viability was reduced by over 50%. Corresponding studies undertaken on primary normal human osteoblast cells (NHOst) demonstrated no adverse effects to the gallium containing glasses. Hydroxyapatite formation was observed for all glasses when exposed to simulated body fluid.
