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Advances in Osteoporotic Bone Tissue Engineering.

Cosmin Iulian Codrea1,2, Alexa-Maria Croitoru1, Cosmin Constantin Baciu3

  • 1Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania.

Journal of Clinical Medicine
|January 15, 2021
PubMed
Summary

This review explores advanced biomaterials and 3D printing for bone tissue engineering to treat osteoporotic fractures. Novel polymer-ceramic scaffolds can locally deliver strontium for enhanced bone healing and reduced side effects.

Keywords:
3D printingbiomaterial scaffoldsboneosteoporosisstrontium ranelate

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Engineering

Background:

  • Osteoporotic fractures represent a growing global health challenge, necessitating innovative bone tissue engineering solutions.
  • Current research focuses on developing advanced biomaterials for bone scaffolds and effective anti-osteoporotic agents.
  • Polymer-ceramic composites, particularly hydroxyapatite with natural/synthetic polymers, show significant promise.

Purpose of the Study:

  • To review the latest advancements in biomaterials for bone tissue engineering, with a focus on polymer-ceramic composites.
  • To compare scaffold fabrication methods and highlight challenges in treating osteoporotic fractures.
  • To discuss the potential of incorporating therapeutic agents like strontium into scaffolds for enhanced bone regeneration.

Main Methods:

  • Literature review of biomaterials, scaffold fabrication techniques, and therapeutic agents for bone regeneration.
  • Emphasis on polymer-ceramic composites and their properties relevant to bone tissue engineering.
  • Analysis of 3D printing advancements for creating complex, drug-eluting scaffolds.

Main Results:

  • Polymer-ceramic composites offer synergistic benefits for bone regeneration.
  • 3D printing enables the fabrication of sophisticated scaffolds for localized drug delivery.
  • Strontium incorporation into scaffolds can enhance osseointegration, osteogenesis, and healing rates.
  • Local delivery of anti-osteoporotic agents minimizes systemic side effects.

Conclusions:

  • Advanced biomaterials and 3D printing are crucial for developing effective bone tissue engineering strategies for osteoporotic fractures.
  • Polymer-ceramic composite scaffolds offer a promising platform for localized delivery of therapeutic agents like strontium.
  • This approach holds significant clinical potential for treating fractured osteoporotic bones with improved safety and efficacy.