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Characterization of a newly established human urinary bladder cancer cell line (BT-1)
1Department of Urology, University of Würzburg, School of Medicine, Federal Republic of Germany.
Urological Research
|January 1, 1988
Abstract:
A new human transitonal cell carcinoma cell line has been established in long term tissue culture. The BT-1 cells were derived from a poorly differentiated human bladder cancer. The tumor cell line produces tumors in nude mice. BT-1 has been characterized by cytogenetic and flow cytometric analysis and by isoenzyme typing. As in direct preparations of human bladder tumors, an isochromosome 5p is a consistent marker of the newly established line. The BT-1 cells produce transforming growth factors but do not respond to exogeneous EGF.