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Related Experiment Video

Updated: Nov 21, 2025

Construction and Characterization of a Novel Vocal Fold Bioreactor
11:11

Construction and Characterization of a Novel Vocal Fold Bioreactor

Published on: August 1, 2014

9.4K

Bioreactors for Vocal Fold Tissue Engineering.

Ana M Gracioso Martins1,2, Andreea Biehl1,2, Daphne Sze1,2

  • 1Joint Department of Biomedical Engineering, College of Engineering, North Carolina State University/University of North Carolina-Chapel Hill, Raleigh, North Carolina, USA.

Tissue Engineering. Part B, Reviews
|January 15, 2021
PubMed
Summary

Vocal fold (VF) tissue engineering uses bioreactors to mimic phonation, aiding in developing therapies for VF disorders. Standardizing bioreactor parameters is crucial for reliable results in VF regeneration research.

Keywords:
bioreactorfibrosisgene expressioninflammationlamina propriavocal fold

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Vocal fold (VF) disorders affect a significant portion of the population, with tissue engineering offering promising therapeutic avenues.
  • VF tissue engineering faces challenges due to the sensitivity of VF tissue properties to mechanical stimulation.
  • Developing effective long-term treatments necessitates characterizing engineered tissues within controlled mechanical environments.

Purpose of the Study:

  • To review the role of bioreactors in vocal fold (VF) tissue engineering.
  • To highlight bioreactors designed to simulate phonation in vitro.
  • To discuss the impact of the phonatory environment on VF development, function, injury, and healing.

Main Methods:

  • Comprehensive review of existing literature on bioreactors for VF tissue engineering.
  • Analysis of bioreactor designs, operational principles, and parameters relevant to phonation.
  • Examination of data on the influence of mechanical stimulation on cellular responses in vitro.

Main Results:

  • Mechanical stimulation in bioreactors significantly impacts cell viability and gene expression related to inflammation and fibrosis.
  • Bioreactors are essential tools for studying VF tissue development and response to mechanical forces.
  • Current data show variability in gene expression, indicating a need for standardization.

Conclusions:

  • Bioreactors are critical for advancing VF tissue engineering and developing therapeutic strategies.
  • Mimicking the phonatory environment in vitro is vital for understanding VF tissue behavior.
  • Standardization of bioreactor parameters and oscillatory regimes is essential for reproducible and comparable research outcomes.