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Updated: Nov 21, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

[Histopathological features due to the SARS-CoV-2].

Paul Hofman¹, Marie-Christine Copin², Arnault Tauziede-Espariat³

¹Laboratoire de pathologie clinique et expérimentale, hôpital Pasteur, centre hospitalo-universitaire de Nice, université Côte d'Azur, B.P. 69-30, avenue de la voie romaine, 06001 Nice cedex 01, France; Biobanque hospitalière (BB-0033-00025), hôpital Pasteur, Nice, France; FHU OncoAge, hôpital Pasteur, Nice, France.

Annales De Pathologie

|January 15, 2021

Summary

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes lesions beyond the respiratory tract, affecting multiple organs. Autopsy studies reveal widespread tissue damage, aiding understanding of COVID-19

Keywords:

Ancillary tools Autopsie Autopsy COVID-19 Pathologie Pathology Pathophysiology Physiopathologie Études ancillaires

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Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

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Published on: December 23, 2020

Area of Science:

Pathology
Infectious Diseases
Molecular Biology

Background:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection primarily affects the respiratory tract but causes lesions in other organs.
Autopsy studies have been crucial in understanding the pathophysiological mechanisms of this emergent infectious disease.
Uncertainties remain regarding the direct role of SARS-CoV-2 in lesions outside the lungs, including the heart, brain, liver, gastrointestinal tract, kidney, and skin.

Purpose of the Study:

To review the main histological and cellular lesions associated with SARS-CoV-2 infection.
To enhance understanding of the consequences of COVID-19 in various organs.
To inform the development of new therapeutic strategies by detailing COVID-19's pathological impact.

Main Methods:

Analysis of autopsy studies.
Detection of SARS-CoV-2 in formalin-fixed paraffin-embedded tissues.
Utilizing immunohistochemistry, in situ hybridization, molecular biology, and electron microscopy.

Main Results:

SARS-CoV-2 infection leads to lesions observed in various organs, tissues, and cells, not exclusively in the respiratory tract.
Autopsy findings have significantly advanced knowledge of COVID-19's pathophysiology.
The direct role of SARS-CoV-2 in extra-pulmonary lesions requires further investigation.

Conclusions:

Continued tissue and cellular studies in COVID-19 patients are essential for a comprehensive understanding of the disease.
Investigating epidemiological and comorbidity factors alongside pathological findings is crucial.
Elucidating the full spectrum of SARS-CoV-2-induced lesions may lead to improved therapeutic interventions.