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Updated: Nov 21, 2025

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
Published on: January 20, 2022
Comment on "Boosted molecular mobility during common chemical reactions"
Jan-Philipp Günther1,2, Lucy L Fillbrook3, Thomas S C MacDonald3
1Max Planck Institute for Intelligent Systems, 70569 Stuttgart, Germany.
Abstract:
The apparent "boosted mobility" observed by Wang et al (Reports, 31 July 2020, p. 537) is the result of a known artifact. When signal intensities are changing during a nuclear magnetic resonance (NMR) diffusion measurement for reasons other than diffusion, the use of monotonically increasing gradient amplitudes produces erroneous diffusion coefficients. We show that no boosted molecular mobility is observed when shuffled gradient amplitudes are applied.
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