Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise and Muscle Performance01:27

Exercise and Muscle Performance

2.1K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
2.1K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

550
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
550
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

1.6K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
1.6K
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.9K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.9K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

3.6K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.6K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted Nrf2 activation improves vascular endothelial function with aging and prevents vascular dysfunction following disuse in younger and older adults.

Free radical biology & medicine·2026
Same author

Is altitude-induced polycythaemia an unintended evolutionary mistake?

Experimental physiology·2026
Same author

Age and sex shape plasma lipid associations to skeletal muscle mitochondrial respiration and H<sub>2</sub>O<sub>2</sub> emission.

GeroScience·2026
Same author

The influence of biological sex on the metabolic basis of skeletal muscle fatigue in vivo.

The Journal of physiology·2025
Same author

Chamber oxygen concentration impacts mitochondrial function and hydrogen peroxide appearance in permeabilized human skeletal muscle fibers.

Biochimica et biophysica acta. Bioenergetics·2025
Same author

Transcriptomic analyses of peripheral blood mononuclear cells reveal age-specific basal and acute exercise responsiveness differences in humans.

American journal of physiology. Endocrinology and metabolism·2025

Related Experiment Video

Updated: Nov 21, 2025

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
07:10

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

10.1K

Exercise training in COPD: muscle O2 transport plasticity.

Ryan M Broxterman1,2, Peter D Wagner3, Russell S Richardson4,2,5

  • 1Dept of Internal Medicine, University of Utah, Salt Lake City, UT, USA ryan.broxterman@utah.edu.

The European Respiratory Journal
|January 15, 2021
PubMed
Summary

Exercise training improved muscle oxygen uptake in COPD patients by enhancing oxygen diffusion. However, limited gains in convective oxygen transport still constrained peak muscle oxygen uptake, indicating a need for targeted interventions.

More Related Videos

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.9K
Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

8.7K

Related Experiment Videos

Last Updated: Nov 21, 2025

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
07:10

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

10.1K
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.9K
Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

8.7K

Area of Science:

  • Physiology
  • Exercise Science
  • Pulmonary Medicine

Background:

  • Skeletal muscle oxygen (O2) transport is reduced in COPD patients.
  • Convective and diffusive O2 transport limitations impact peak muscle O2 uptake (V'mO) in COPD.
  • The response of these O2 transport determinants to exercise training in COPD is not well understood.

Purpose of the Study:

  • To investigate the plasticity of skeletal muscle O2 transport determinants of V'mO following exercise training in COPD patients.
  • To compare adaptations in convective and diffusive O2 transport between COPD patients and healthy controls.

Main Methods:

  • Eight weeks of single-leg knee-extensor exercise training in severe COPD patients and healthy controls.
  • Measurement of femoral arterial and venous blood gases and leg blood flow.
  • Determination of muscle O2 transport and utilization at maximal exercise pre- and post-training.

Main Results:

  • Exercise training increased V'mO in both groups, but COPD patients reached ~80% of pre-training control V'mO.
  • Muscle diffusive O2 transport increased significantly in both groups, reaching ~90% of pre-training control values in COPD.
  • Muscle convective O2 transport increased only in controls, leaving COPD patients at ~70% of pre-training control values.

Conclusions:

  • Exercise training largely restored muscle diffusive O2 transport in COPD patients.
  • Peak muscle O2 uptake (V'mO) in COPD remains limited by the reduced plasticity of muscle convective O2 transport.
  • Targeted interventions may be needed to improve convective O2 transport and further enhance exercise capacity in COPD.