Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

Unusual Results

Unusual Results

Unusual results are those that have a very low chance of occurring. Unusual results can be identified using probabilities and the range rule of thumb. In problems involving probability, unusual results can be observed in 2 instances – an unusually high number of successes or an unusually low number of successes.
According to the range rule of thumb, any value above or below two standard deviations, 2σ from the mean, μ is considered unusual.
Maximum unusual value =...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Insights in pharmacological activities and the gastrointestinal stability of paraconic acids from Cetraria islandica (L.) Ach.

Journal of ethnopharmacology·2026

Same author

Perovskone, a potential antiprotozoal hit compound, quantification and derivatization.

Scientific reports·2026

Same author

Non-targeted metabolomics and postbiotics survey of an Iranian Koupa cheese Lactiplantibacillus plantarum isolate.

Scientific reports·2026

Same author

Partial characterization and evaluation of antioxidant and antibacterial activities of a water soluble polysaccharide isolated from Euphorbia hebecarpa roots.

Scientific reports·2026

Same author

Variation in phytochemical profiles and anti-cholinesterase activity across wild Iranian populations of Leucojum aestivum L.: a conservation perspective.

BMC plant biology·2026

Same author

Plumericin Modulates the AhR-NFκB-Nrf2 Signaling Network to Counteract Indoxyl Sulfate-Induced Intestinal Epithelial Cells Impairment.

International journal of molecular sciences·2026

Search research articles

Related Experiment Video

Updated: Nov 21, 2025

Scanning Electron Microscopy SEM Protocols for Problematic Plant, Oomycete, and Fungal Samples

Scanning Electron Microscopy SEM Protocols for Problematic Plant, Oomycete, and Fungal Samples

Published on: February 3, 2017

Unusual derivatives from Hypericum scabrum.

Sara Soroury^1,2, Mostafa Alilou³, Thomas Gelbrich⁴

¹Department of Phytochemistry, Faculty of Science, Golestan University, 15759-49138, Gorgan, Iran.

Scientific Reports

|January 15, 2021

Summary

This summary is machine-generated.

Three novel compounds with unique structures were isolated from Hypericum scabrum. Compound 1 demonstrated moderate antiprotozoal activity against Trypanosoma brucei and Plasmodium falciparum.

More Related Videos

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Published on: November 18, 2022

Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry

Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry

Published on: February 2, 2024

Related Experiment Videos

Last Updated: Nov 21, 2025

Scanning Electron Microscopy SEM Protocols for Problematic Plant, Oomycete, and Fungal Samples

Scanning Electron Microscopy SEM Protocols for Problematic Plant, Oomycete, and Fungal Samples

Published on: February 3, 2017

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Published on: November 18, 2022

Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry

Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry

Published on: February 2, 2024

Area of Science:

Natural Product Chemistry
Medicinal Chemistry
Phytochemistry

Background:

Hypericum species are known sources of bioactive compounds.
Exploring novel chemical entities from medicinal plants is crucial for drug discovery.

Purpose of the Study:

To isolate and characterize new compounds from Hypericum scabrum.
To evaluate the antiprotozoal and cytotoxic activities of the isolated compounds.

Main Methods:

Isolation via n-hexane extraction.
Structure elucidation using extensive spectroscopic (NMR, HRESI-TOFMS) and spectrometric techniques.
Absolute configuration determination via ECD calculations and single crystal X-ray diffraction.

Main Results:

Three new compounds (1-3) with unusual skeletons were identified.
Compound 1: First esterified polycyclic polyprenylated acylphloroglucinol with a tricyclo-[4.3.1.1^1,4]-undecane skeleton.
Compound 2: MPAP with a cycloheptane ring and prenyl substituents.
Compound 3: Possesses a 5,5-spiroketal lactone core.
Compound 1 exhibited moderate in vitro activity against Trypanosoma brucei rhodesiense (IC₅₀ 3.07 μM) and Plasmodium falciparum (IC₅₀ 2.25 μM).

Conclusions:

The study successfully isolated and characterized three novel compounds from Hypericum scabrum.
The findings highlight the potential of Hypericum scabrum as a source of structurally unique and biologically active natural products.
Compound 1 shows promise for further investigation as an antiprotozoal agent.