Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

QRS morphology-dependent pharmacodynamics in multiform ventricular ectopic activity.

K M Kessler1, D McAuliffe, P Kozlovskis

  • 1Department of Medicine, University of Miami School of Medicine, Florida.

The American Journal of Cardiology
|March 1, 1988
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of particle size and interparticle force on the fluidization behavior of gas-fluidized beds.

Physical review. E, Statistical, nonlinear, and soft matter physics·2003
Same author

Pumping of liquids with ac voltages applied to asymmetric pairs of microelectrodes.

Physical review. E, Statistical, nonlinear, and soft matter physics·2003
Same author

Experimental study on the dynamics of gas-fluidized beds.

Physical review. E, Statistical, nonlinear, and soft matter physics·2003
Same author

Fluid flow induced by nonuniform ac electric fields in electrolytes on microelectrodes. III. Observation of streamlines and numerical simulation.

Physical review. E, Statistical, nonlinear, and soft matter physics·2002
Same author

Fine cohesive powders in rotating drums: Transition from rigid-plastic flow to gas-fluidized regime.

Physical review. E, Statistical, nonlinear, and soft matter physics·2002
Same author

Sudden death due to cardiac arrhythmias.

The New England journal of medicine·2002

Procainamide infusion differentially suppressed ventricular premature complexes (VPCs) with varying QRS morphologies in most patients. Specific suppression patterns suggest a targeted pharmacologic effect on VPC origins.

Area of Science:

  • Cardiology
  • Pharmacology
  • Electrophysiology

Background:

  • Multiform ventricular premature complexes (VPCs) present a complex clinical challenge.
  • Understanding the differential effects of antiarrhythmic drugs on VPCs is crucial for effective treatment.

Purpose of the Study:

  • To investigate the differential effects of intravenous procainamide on ventricular premature complexes (VPCs) with distinct QRS morphologies.
  • To determine if procainamide exhibits a selective suppression pattern based on VPC morphology.

Main Methods:

  • Twenty patients with multiform VPCs received intravenous procainamide infusions.
  • The frequency and suppression patterns of VPCs with different QRS morphologies were monitored.
  • Procainamide levels at VPC escape and duration of suppression were analyzed.

Related Experiment Videos

Main Results:

  • Seventeen out of 20 patients showed differential suppression of VPCs based on QRS morphology.
  • In some patients, the most frequent VPC morphology was suppressed longer/at lower concentrations; in others, the second most frequent was.
  • These specific suppression patterns were independent of the initial frequency of each VPC morphology.

Conclusions:

  • Procainamide demonstrates a differential pharmacologic effect on the foci or pathways generating distinct VPC morphologies.
  • Individualized suppression patterns of VPCs suggest targeted therapeutic strategies may be possible.
  • Further research into the electrophysiologic basis of differential VPC suppression is warranted.