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Intrinsic left ventricular contractility in normal subjects.

M W Kronenberg1, J P Uetrecht, W D Dupont

  • 1Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.

The American Journal of Cardiology
|March 1, 1988
PubMed
Summary
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Autonomic tone does not significantly influence resting left ventricular (LV) contractility in healthy individuals. However, LV contractility, measured by pressure-volume relations, is sensitive to exercise and reproducible in serial studies.

Area of Science:

  • Cardiology
  • Physiology

Background:

  • Autonomic tone plays a role in cardiovascular regulation.
  • Understanding left ventricular (LV) contractility is crucial for assessing cardiac function.

Purpose of the Study:

  • To investigate the influence of autonomic tone on LV contractility in normal subjects.
  • To determine the range of normal LV contractility values.
  • To assess the effects of exercise on LV contractile state and the reproducibility of measurements.

Main Methods:

  • LV contractility assessed using LV peak-systolic pressure to end-systolic volume relation (pressure-volume relation) and pressure/volume ratio.
  • Measurements taken at rest, during exercise, and pharmacologic pressure-afterloading.
  • Vagal and beta-adrenergic blockade performed before and after interventions.

Related Experiment Videos

  • Cuff blood pressure and radionuclide ventriculography utilized.

    • Main Results:

    • Both pressure/volume ratio and ejection fraction increased significantly during exercise (p ≤ 0.008).
    • Autonomic blockade did not alter the linearity or slope of pressure-volume relations.
    • Serial studies demonstrated high reproducibility of pressure-volume relations (r = 0.95 ± 0.05).

    Conclusions:

    • Resting LV contractility in normal subjects is not significantly supported by vagal or sympathetic tone.
    • The pressure-volume relation and pressure/volume ratio are reproducible, supporting serial studies.
    • Exercise significantly impacts LV contractility, as evidenced by changes in pressure/volume ratio and ejection fraction.