Related Experiment Video

Updated: Aug 15, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

7.0K

Thromboelastography Profile of Patients with COVID-19 Admitted to Intensive Care Unit: A Single-center Retrospective

Sanjith Saseedharan1, Vijay B Talla2, Annapurna Chiluka1

  • 1Department of Intensive Care Unit, SL Raheja Hospital, Mumbai, Maharashtra, India.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
|January 15, 2021
PubMed

Insights

Thromboelastography (TEG) reveals significant hypercoagulation in COVID-19 patients, indicating potential for predicting venous thromboembolism (VTE) events. This viscoelastic test offers a dynamic view of coagulation function in intensive care unit (ICU) patients.

Area of Science:

  • Critical Care Medicine
  • Hematology
  • Infectious Diseases

Background:

  • Coronavirus disease (COVID-19) is associated with thromboinflammation and a high incidence of venous thromboembolism (VTE).
  • Standard thromboprophylaxis with low-molecular-weight heparins is often insufficient to prevent VTE in COVID-19 patients.
  • Traditional coagulation markers provide a static view, necessitating dynamic assessments for better understanding of hypercoagulability.

Purpose of the Study:

  • To analyze thromboelastography (TEG) profiles in intensive care unit (ICU) patients with COVID-19.
  • To assess the utility of TEG in identifying and understanding COVID-19-related hypercoagulability.
  • To explore the potential of TEG in predicting venous thromboembolism (VTE) events in these patients.

Main Methods:

  • Retrospective analysis of thromboelastography (TEG) values from 32 COVID-19 patients admitted to the ICU.
  • Evaluation of TEG parameters including R, K, Angle, MA, and Coagulation Index (CI) against normal reference ranges (NRR).
  • Comparison of TEG findings with disease severity and non-COVID ICU patient data.

Main Results:

  • Hypercoagulation, defined by a TEG-Coagulation Index (CI) above the upper limit of the normal reference range (NRR), was observed in 62.5% of patients.
  • Specific TEG parameters (R, K, LY30 lower; Angle, MA, CI higher than NRR) indicated hypercoagulability, more pronounced in severe COVID-19.
  • Findings were largely consistent with prior studies, with LY30 retention noted in most patients.

Conclusions:

  • Thromboelastography (TEG) is a valuable tool for assessing and screening COVID-19-associated hypercoagulability.
  • TEG may aid in predicting venous thromboembolism (VTE) risk in critically ill COVID-19 patients.
  • Further prospective studies are needed to evaluate TEG's role in guiding optimal anticoagulant therapy.

Keywords:
Coagulation disorderCoronavirus diseaseIntensive care unitThromboelastography

More Related Videos

Author Spotlight: Advancing Thrombolytic Testing by Integrating Flow Dynamics in In Vitro Models06:16

Author Spotlight: Advancing Thrombolytic Testing by Integrating Flow Dynamics in In Vitro Models

Published on: April 19, 2024

1.4K
Author Spotlight: Accelerating Diagnostic Accuracy with Direct Identification of Gram-Negatives from Blood Culture Bottles09:07

Author Spotlight: Accelerating Diagnostic Accuracy with Direct Identification of Gram-Negatives from Blood Culture Bottles

Published on: May 24, 2024

1.2K

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Pulmonary Embolism I: Introduction01:19

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...