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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

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Stickler Syndrome (SS): Laser Prophylaxis for Retinal Detachment (Modified Ora Secunda Cerclage, OSC/SS).

Robert E Morris1,2,3,4, Edward Scott Parma5, Nathaniel H Robin6

  • 1Retina Specialists of Alabama, Birmingham, AL, USA.

Clinical Ophthalmology (Auckland, N.Z.)
|January 15, 2021
PubMed
Summary
This summary is machine-generated.

Encircling laser prophylaxis (OSC/SS) offers a promising option to prevent retinal detachment in Stickler syndrome patients. This novel technique shows significant success in maintaining visual acuity and preventing RRD in treated eyes.

Keywords:
OSCOSC/SSOra Secunda CerclageSSSTL1STL2Stickler syndromeencircling laser prophylaxisgiant retinal tearretinal detachment prevention

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Area of Science:

  • Ophthalmology
  • Retinal Surgery
  • Genetics

Background:

  • Stickler syndrome (STL) is a genetic disorder associated with an increased risk of rhegmatogenous retinal detachment (RRD).
  • Traditional prophylactic treatments for RRD in STL eyes have limitations.
  • A novel encircling laser prophylaxis (OSC/SS) technique has been developed.

Observation:

  • The study involved patients with type 2 Stickler syndrome (STL2) who underwent OSC/SS prophylaxis in one or both eyes.
  • Family members with STL2 experienced a high rate of RRD (83%) without prophylaxis.
  • The OSC/SS procedure was performed on fellow eyes of patients who had already experienced RRD in one eye.

Findings:

  • The three OSC/SS treated fellow eyes remained free of RRD for 12, 11, and 8 years post-procedure.
  • The single STL2 patient with bilateral OSC/SS prophylaxis remained bilaterally attached.
  • Eyes treated with OSC/SS maintained preoperative visual acuity (20/20 to 20/30) with a moderate, asymptomatic reduction in visual field.
  • Eyes that suffered RRD prior to treatment had significantly worse visual acuity and a more restricted visual field.

Implications:

  • Encircling laser prophylaxis (OSC/SS) is a viable RRD prophylaxis option for Stickler syndrome patients (STL1 and STL2).
  • OSC/SS offers an alternative to no treatment or less effective prophylactic methods.
  • Further non-randomized, prospective cohort studies are needed to confirm the long-term safety and efficacy due to the rarity of the condition.