Related Experiment Video
Updated: Nov 21, 2025
08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
3.1K
COVID-19 and Possible Pharmacological Preventive Options
1Department of Clinical Science, SUS, Experimental Cardiovascular research, University of Lund, Sweden.
Journal of Clinical Medicine Research
|January 15, 2021
Summary
Early COVID-19 treatment may require combining antiviral drugs with immune-boosting therapies or convalescent plasma. This approach could offer better outcomes than single-drug treatments for coronavirus disease 2019 (COVID-19).
Area of Science:
- Infectious Diseases
- Pharmacology
- Immunology
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, presents significant mortality risks.
- The early stages of the outbreak necessitated rapid identification of potential pharmacological treatments.
- Pathogenesis involves elevated pro-inflammatory cytokines, hypoxia, thromboembolism, and pneumonia.
Purpose of the Study:
- To explore existing pharmacological options for preventing or treating early-stage COVID-19.
- To review available drugs and theoretical treatment combinations.
Main Methods:
- Conducted a literature search using PubMed and internet resources.
- Identified and reviewed studies related to COVID-19 treatments.
Main Results:
- Monotherapy regimens with tested drugs showed variable or undesirable effects.
- Combined therapeutic strategies are theoretically more promising than single-drug approaches.
- Key factors in SARS-CoV-2 infection include cytokine imbalance, hypoxia, and thromboembolism.
Conclusions:
- Simultaneously targeting the virus and its symptoms is a viable strategy.
- Combination therapy, such as using multiple antivirals with immunomodulators or convalescent plasma, may improve COVID-19 treatment efficacy.
- Further research into combination therapies is warranted for effective COVID-19 management.
Related Concept Videos
01:30Preventive Healthcare Services
1.5K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.5K
01:17Transmission-based Precautions I: Contact, Enteric, and Droplets
4.3K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
4.3K
01:26Coronary Artery Disease IV: Preventive Measures
476
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
476
01:26Pharmacokinetics: Drug–Food and Drug–Viral Interactions
80
A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
80
01:25Transmission-based Precautions II: Airborne and Protective Environment
1.7K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.7K
01:25Cardiopulmonary Resuscitation IV: Pharmacological Management
251
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
251