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Effect of Strontium Ranelate on Condylar Growth during Mandibular Advancement in Rats
Hasan Camcı1, Cenk Doruk2, Serpil Ünver Saraydın3
1Department of Orthodontics, Afyonkarahisar Sağlık Bilimleri University, Afyonkarahisar, Turkey.
Turkish Journal of Orthodontics
|January 15, 2021
Summary
Strontium ranelate (SR) enhances condylar growth during mandibular advancement (MA) in rats by promoting bone formation. This suggests SR may be beneficial in orthodontic treatments to prevent relapse.
Area of Science:
- Orthodontics
- Bone Biology
- Pharmacology
Background:
- Strontium ranelate (SR) is an anti-osteoporotic agent with potential bone-forming properties.
- Mandibular advancement (MA) is a common orthodontic treatment for skeletal discrepancies.
Purpose of the Study:
- To investigate the effects of systemic SR on condylar growth during MA in growing rats.
- To assess SR's impact on cartilage and bone formation markers in the mandibular condyle.
Main Methods:
- Wistar rats underwent MA with or without SR administration.
- Computed tomography (CT) evaluated mandibular growth.
- Immunohistochemistry assessed Sox9 and Osteopontin expression in condylar cartilage and bone.
Main Results:
- CT measurements showed no significant difference in mandibular growth between groups.
- Immunohistochemical analysis revealed significantly higher Sox9 and Osteopontin expression in the SR+MA group.
- SR alone and MA alone showed moderate increases in these markers compared to controls.
Conclusions:
- Strontium ranelate may enhance bone formation during mandibular advancement.
- SR could be a valuable adjunct in MA therapy to improve stability and reduce relapse.
- Further research is needed to confirm these findings in clinical settings.
