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Related Experiment Video

Updated: Nov 21, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
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Salmonella thyroid abscess-two case reports.

Kah Seng Khoo1, Peng Soon Koh2, Khoon Leong Ng3

  • 1Surgical Resident, Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Gland Surgery
|January 15, 2021
PubMed
Summary

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Acute suppurative thyroiditis is rare, especially Salmonella thyroid abscesses. Two immunocompromised patients developed Salmonella thyroid abscesses without gastrointestinal issues, requiring surgical intervention for recovery.

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Surgical Pathology

Background:

  • Acute suppurative thyroiditis is a rare condition (<1% of thyroid diseases) due to the thyroid gland's protective anatomical and physiological features.
  • Commonly caused by Staphylococci and Streptococci, rarer pathogens like Salmonella spp. are infrequently reported, with only 28 cases of Salmonella thyroid abscess documented globally by 2020.

Observation:

  • This report details two cases of Salmonella enteritidis thyroid abscess in immunocompromised patients presenting with neck swelling, dysphagia, and sepsis.
  • Neither patient had gastrointestinal involvement, a typical association with Salmonella infections.
  • Both cases necessitated surgical intervention due to disease severity and failure of medical management.

Findings:

  • Successful recovery was achieved in both patients following surgical drainage and targeted antibiotic therapy based on pathogen culture and sensitivity.
Keywords:
InfectionSalmonellacase reportthyroid abscess

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  • The cases suggest a potential re-emergence of Salmonella thyroid abscess, particularly in immunocompromised individuals.

    • Implications:

    • Highlights the importance of a high index of suspicion for Salmonella thyroid abscess in immunocompromised patients, even without gastrointestinal symptoms.
    • Emphasizes prompt diagnosis and appropriate management, including antibiotics, percutaneous aspiration, or surgical drainage, for effective treatment of this rare condition.