Single-Atom Catalysts for Nanocatalytic Tumor Therapy

Area of Science:

• Catalysis
• Nanotechnology
• Oncology

Background:

• Single-atom catalysts (SACs) are gaining attention for their unique properties, including precise metal centers and tunable structures.
• Nanocatalytic medicine offers a novel approach to tumor chemotherapy, avoiding toxic chemodrugs.
• SACs possess characteristics ideal for developing effective catalytic tumor therapies.

Purpose of the Study:

• To review recent advancements in nanocatalytic tumor therapy utilizing various single-atom catalysts (SACs).
• To focus on the construction of catalytic nanoplatforms and the underlying catalytic mechanisms.
• To provide an outlook on future design and engineering of SACs for tumor treatment.

Main Methods:

• Review of recent literature on single-atom catalysts (SACs) in nanocatalytic tumor therapy.
• Analysis of SAC applications in chemodynamic therapy (CDT), photodynamic therapy (PDT), and sonodynamic therapy (SDT).
• Focus on nanoplatform design and catalytic mechanisms for tumor treatment.

Main Results:

• SACs demonstrate significant achievements in various nanocatalytic tumor therapy modalities.
• Tumor microenvironment-responsive reactions, photocatalysis, and sonocatalysis are key mechanisms.
• Effective nanoplatform construction is crucial for SAC-based tumor therapy.

Conclusions:

• Single-atom catalysts (SACs) are highly promising for advanced nanocatalytic tumor therapy.
• Further research into nanoplatform design and catalytic mechanisms will enhance SAC efficacy.
• Addressing remaining challenges is key for future clinical translation of SACs in oncology.