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Related Experiment Videos

Left ventricular function during chronic endotoxemia in swine.

K Lee1, H van der Zee, S W Dziuban

  • 1Department of Physiology, Albany Medical College, New York 12208.

The American Journal of Physiology
|February 11, 1988
PubMed
Summary
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Chronic endotoxemia (CET) in pigs, a model for hyperdynamic sepsis, depressed cardiac function. Despite elevated cardiac output and heart rate, the left ventricular inotropic state was impaired, as shown by reduced end-systolic pressure-diameter relationship (ESPDR).

Area of Science:

  • Cardiovascular Physiology
  • Sepsis Pathophysiology
  • Animal Models in Research

Background:

  • Sepsis is characterized by complex cardiovascular alterations, including a hyperdynamic state.
  • The impact of chronic endotoxemia on left ventricular inotropic state remains incompletely understood.
  • Understanding cardiac performance during sepsis is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the hypothesis that left ventricular inotropic state is depressed during chronic endotoxemia (CET) in a porcine model.
  • To assess cardiac performance using load-independent parameters during the hyperdynamic sepsis phase.
  • To evaluate the relationship between endotoxemia and cardiac contractility.

Main Methods:

  • 15 pigs were instrumented and subjected to chronic endotoxemia (CET) via endotoxin infusion.

Related Experiment Videos

  • Cardiac performance was monitored using left ventricular pressure, short axis diameter (SAX), pulmonary artery flow, and ECG.
  • Key parameters measured included dP/dt, heart rate, stroke volume, and the end-systolic pressure-diameter relationship (ESPDR).

    • Main Results:

    • Surviving pigs (10/15) exhibited elevated systolic pressures, heart rates, and cardiac output during CET.
    • Despite the hyperdynamic state, the end-systolic pressure-diameter relationship (ESPDR) was significantly depressed.
    • Percent short axis (SAX) shortening, another indicator of contractility, was also significantly reduced during CET.

    Conclusions:

    • Cardiac inotropic state is depressed during hyperdynamic sepsis, as evidenced by a reduced load-independent parameter, ESPDR.
    • The findings confirm impaired left ventricular contractility in the chronic endotoxemia model.
    • This study highlights the detrimental effects of sustained endotoxemia on cardiac function.