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Updated: Nov 21, 2025
Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
Amputation With Osseointegration for Patients With Intractable Complex Regional Pain Syndrome: A Report of 3 Cases
Jason Shih Hoellwarth1,2, Shakib Sameeh Al-Jawazneh2,3, Kevin Tetsworth4
1Baylor College of Medicine, Department of Pediatric Orthopaedics, Texas Children's Hospital, Houston, Texas.
Cases:
Three patients with knee-level complex regional pain syndrome type 1 (CRPS1), recalcitrant to conservative interventions, elected for transfemoral amputation and osseointegration. Two patients gained independent ambulation; the third remains on crutches after a disrupted sciatic nerve targeted reinnervation. One uses no pain medication, one is weaning off, and one requires a reduced regimen after revision nerve innervation.
Conclusion:
Osseointegration seems suitable to optimize rehabilitation after amputation for CRPS1.
