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Lessons on SpA pathogenesis from animal models.

Maxime Breban1,2,3, Simon Glatigny4,5, Bilade Cherqaoui4,5

  • 1Infection & Inflammation, UMR 1173, Inserm, UVSQ/Université Paris Saclay, 2 ave de la Source de la Bièvre, 78180, Montigny-le-Bretonneux, France. maxime.breban@aphp.fr.

Seminars in Immunopathology
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Summary
This summary is machine-generated.

Animal models are crucial for understanding spondyloarthritis (SpA) mechanisms, particularly the roles of genetics and immune pathways like IL-23/IL-17. These models aid in exploring new therapeutic targets for SpA.

Keywords:
Animal modelsAnkylosing spondylitisHLA-B27Interleukin-17Interleukin-23SpondyloarthritisTNFα

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Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Background:

  • Spondyloarthritis (SpA) pathogenesis involves complex genetic and immune factors.
  • Animal models are essential tools for dissecting SpA mechanisms.
  • Key genetic factors include HLA-B27, ERAP1, and the IL-23/IL-17 axis.

Purpose of the Study:

  • To review the utility of various animal models in understanding SpA.
  • To highlight how these models elucidate genetic predispositions and immune dysregulation in SpA.
  • To identify potential therapeutic targets through preclinical research.

Main Methods:

  • Review of existing literature on SpA animal models.
  • Analysis of genetic factors (HLA-B27, ERAP1, IL-23/IL-17 axis) in disease development.
  • Examination of findings from transgenic rat, Drosophila, and various mouse models.

Main Results:

  • The HLA-B27 transgenic rat model advanced theories on SpA pathogenicity, immunity, and microbiota influence.
  • Drosophila models revealed novel roles for TGFβ/BMP signaling in SpA.
  • Mouse models underscored the significance of TNFα and the IL-23/IL-17 axis in SpA.

Conclusions:

  • Animal models are invaluable for studying SpA mechanisms, including genetic and immune system contributions.
  • These models provide insights into the role of microbiota and novel signaling pathways.
  • Preclinical research using these models facilitates the investigation of potential therapeutic strategies for SpA.