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Severe anaphylactoid reaction to nalidixic acid.
R Valdivieso1, J Pola, E Losada
1Department of Allergy, Hospital Ramon y Cajal, Madrid, Spain.
Allergy
|January 1, 1988
Summary
A woman experienced a severe anaphylactoid reaction to nalidixic acid, a urinary tract infection treatment. This adverse drug reaction, confirmed by provocation testing, appears to be a novel response to this medication.
Area of Science:
- Pharmacology
- Clinical Medicine
- Toxicology
Background:
- Nalidixic acid is an antibiotic commonly prescribed for urinary tract infections.
- Adverse drug reactions can range from mild to severe, impacting patient safety.
- Anaphylactoid reactions are immediate hypersensitivity responses that mimic anaphylaxis.
Observation:
- A 58-year-old non-atopic woman developed an adverse reaction after taking oral nalidixic acid.
- The patient exhibited symptoms of an anaphylactoid reaction within 3 minutes of drug administration.
- Standard allergy tests, including skin and histamine release tests, were negative.
Findings:
- A single-blind oral provocation test confirmed nalidixic acid as the cause of the anaphylactoid reaction.
- The observed reaction pattern is not previously documented for nalidixic acid.
- The negative skin and histamine release tests suggest a non-IgE mediated hypersensitivity mechanism.
Implications:
- This case highlights a potentially new adverse drug reaction profile for nalidixic acid.
- Clinicians should be aware of the possibility of anaphylactoid reactions to nalidixic acid, even in non-atopic individuals.
- Further research may be needed to elucidate the mechanism of this previously undescribed reaction.