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Functional DNA Based Hydrogels: Development, Properties and Biological Applications.

Vinod Morya1, Shanka Walia1, Biman B Mandal2

  • 1Biological Engineering Discipline, Indian Institute of Technology Gandhinagar, Palaj, Gujarat 382355, India.

ACS Biomaterials Science & Engineering
|January 15, 2021
PubMed
Summary

DNA hydrogels are versatile nanoscale materials for biomedical applications. This review covers their synthesis, properties, and use in biosensing, bioimaging, drug delivery, and cellular programming for theranostics.

Keywords:
DNA hydrogelsbiosensingdrug deliveryself-assemblytissue engineering

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • DNA's unique structural and functional properties make it ideal for nanoscale construction.
  • DNA-based hydrogels are gaining prominence for their applications in biosensing, bioimaging, and therapeutics.

Purpose of the Study:

  • To summarize recent advancements in DNA hydrogels for biomedical applications.
  • To review synthetic strategies, characterization techniques, and diverse applications of DNA hydrogels.

Main Methods:

  • Classification of DNA hydrogels based on structural motifs and spatial arrangements.
  • Characterization using advanced imaging and biophysical techniques.
  • Review of applications in biosensing, bioimaging, drug delivery, and cellular programming.

Main Results:

  • Multiple synthetic routes for DNA hydrogels are available.
  • DNA hydrogels exhibit tunable properties suitable for various biomedical tasks.
  • Applications span diagnostics, therapeutics, and regenerative medicine.

Conclusions:

  • DNA hydrogels represent a promising class of materials for theranostic devices.
  • Their versatility supports development of advanced therapeutic and biological tools.