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PRIASE 2021 guidelines for reporting animal studies in Endodontology: a consensus-based development
V Nagendrababu1, A Kishen2, P E Murray3
1Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, UAE.
International Endodontic Journal
|January 15, 2021
Summary
New guidelines called Preferred Reporting Items for Animal Studies in Endodontology (PRIASE) 2021 improve animal research quality. These guidelines enhance the reliability and repeatability of endodontic studies.
Area of Science:
- Endodontology
- Animal Research Reporting
Background:
- Animal testing is vital when human research poses risks or ethical issues.
- Standardized reporting is needed for animal studies in endodontology.
Purpose of the Study:
- To develop exclusive reporting guidelines for animal studies in endodontology.
- To establish the Preferred Reporting Items for Animal Studies in Endodontology (PRIASE) 2021 guidelines.
Main Methods:
- A consensus-based methodology was employed.
- Guidelines were adapted from ARRIVE and CLIP principles.
- A Delphi process and online meetings involved 31 and 21 participants, respectively.
Main Results:
- The PRIASE 2021 guidelines comprise an 11-domain, 43-item checklist and a flowchart.
- Consensus was achieved on checklist items and the flowchart.
- Guidelines were modified based on feedback and piloted by authors.
Conclusions:
- PRIASE 2021 aims to enhance methodological rigor, reproducibility, and quality in endodontic animal studies.
- Improved reliability and repeatability will aid in estimating treatment effects and guiding future human clinical studies.
