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Temporal orienting in Parkinson's disease.

Nahid Zokaei1,2, Celine R Gillebert2,3, Joshua J Chauvin1,2

  • 1Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, UK.

The European Journal of Neuroscience
|January 15, 2021
PubMed
Summary
This summary is machine-generated.

Individuals with Parkinson's disease (PD) show deficits in temporal attention, particularly when discriminating targets amidst distractors. Dopamine medication can restore this temporal orienting ability in perceptual tasks.

Keywords:
Parkinson's diseaseRSVPattentionexpectationtemporal orienting

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Area of Science:

  • Cognitive Neuroscience
  • Neurodegenerative Diseases

Background:

  • Temporal orienting of attention influences processing stages for adaptive behavior.
  • Parkinson's disease (PD) may impact temporal expectation abilities.

Purpose of the Study:

  • To investigate if temporal expectation is compromised in individuals with Parkinson's disease (PD).
  • To examine the influence of task context and dopaminergic medication on temporal orienting in PD.

Main Methods:

  • Two temporal-orienting tasks were employed: a speeded motor preparation task and a non-speeded perceptual discrimination task.
  • Auditory cues indicated target probability at short or long intervals.
  • Experiment 2 explored the role of distractors and dopaminergic medication status.

Main Results:

  • Individuals with PD showed intact temporal orienting in a speeded task but were impaired in perceptual discrimination.
  • This perceptual deficit was abolished by dopaminergic medication and absent in a task without distractors.
  • PD-related temporal orienting deficits are task-dependent, especially concerning distractor interference.

Conclusions:

  • Temporal orienting deficits in Parkinson's disease are modulated by task demands, particularly the need to filter distractors.
  • Dopaminergic medication can ameliorate temporal orienting impairments in perceptual tasks for individuals with PD.