Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

222
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
222
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

84
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
84
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

2.2K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
2.2K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

267
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
267
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

84
In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
84
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

85
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
85

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From standard to stratified: Modeling NTCP and EAR to personalize daily MV-CBCT in radiotherapy.

Journal of applied clinical medical physics·2025
Same author

Comparison of visual and semi-automated kilovoltage cone beam CT image QA analysis.

Journal of applied clinical medical physics·2023
Same author

Creating a treatment plan report should be mandated as a minimum standard practice for patient care and QA documentation.

Journal of applied clinical medical physics·2020
Same author

The relationship between ventricular volume and whole-brain irradiation dose in central nervous system germ cell tumors.

Pediatric blood & cancer·2019
Same author

Acute toxicity of craniospinal irradiation with volumetric-modulated arc therapy in children with solid tumors.

Pediatric blood & cancer·2018
Same journal

Synthetic CT-enabled weekly adaptive radiotherapy for nasopharyngeal carcinoma: Optimizing plan adaptation triggers through volumetric-dosimetric monitoring.

Journal of applied clinical medical physics·2026
Same journal

Method for simultaneous selection of treatment isocenters and margins for polymetastatic extracranial stereotactic ablative radiotherapy.

Journal of applied clinical medical physics·2026
Same journal

Pulse‑level characterization of low monitor unit deliveries on a modern linear accelerator using a plastic scintillation detector.

Journal of applied clinical medical physics·2026
Same journal

Improving image quality in terbium-161 phantom imaging: Quantitative evaluation of DEW and TEW scatter correction methods.

Journal of applied clinical medical physics·2026
Same journal

Latent density discrepancies in commercial lung-equivalent inserts and their clinical dosimetric impact.

Journal of applied clinical medical physics·2026
Same journal

Explainable machine learning for patient-specific quality assurance in intensity-modulated radiotherapy based on anatomical structures.

Journal of applied clinical medical physics·2026
See all related articles

Related Experiment Video

Updated: Nov 21, 2025

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

47.2K

How low can you go? A CBCT dose reduction study.

Arthur J Olch1, Parham Alaei2

  • 1Radiation Oncology Program, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Journal of Applied Clinical Medical Physics
|January 15, 2021
PubMed
Summary
This summary is machine-generated.

Reducing cone beam computed tomography (CBCT) dose significantly lowers radiation exposure for bony anatomy-based image-guided radiation therapy (IGRT). This reduced dose maintains or improves patient positioning accuracy compared to standard kV imaging, especially for rotational corrections.

Keywords:
CBCTimage gentlyimaging dose

More Related Videos

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

16.2K
Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
09:49

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

10.5K

Related Experiment Videos

Last Updated: Nov 21, 2025

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

47.2K
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

16.2K
Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
09:49

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

10.5K

Area of Science:

  • Medical Physics
  • Radiotherapy
  • Diagnostic Imaging

Background:

  • Cone beam computed tomography (CBCT) is integral for image-guided radiation therapy (IGRT), primarily utilizing bony anatomy for patient setup.
  • Current CBCT protocols involve significant radiation doses, raising concerns about cumulative patient exposure.

Purpose of the Study:

  • To investigate the feasibility of reducing CBCT radiation dose to levels comparable to kV image pairs.
  • To assess if dose reduction compromises positioning accuracy in bony anatomy-based IGRT.

Main Methods:

  • Anthropomorphic phantoms were imaged in various regions using standard and reduced-dose CBCT protocols.
  • Image registration (2D/3D) was performed using six degrees of freedom for both reduced-dose CBCT and standard kV image pairs.
  • Radiation doses were measured following TG-61 formalism.

Main Results:

  • CBCT dose was reduced by 81-98%, achieving levels similar to kV image pairs.
  • Translational shifts for reduced-dose CBCT were within 0.3 mm, and rotational shifts within 0.2 degrees.
  • Positioning accuracy with reduced-dose CBCT was comparable or superior to kV image pairs.

Conclusions:

  • CBCT dose can be substantially reduced for bony anatomy-based IGRT without sacrificing positioning accuracy.
  • Reduced-dose CBCT offers superior rotational correction capabilities compared to kV imaging.
  • This approach is particularly beneficial for pediatric radiation therapy, minimizing radiation burden.