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Related Experiment Videos

Amoxapine cardiotoxicity.

M A Munger1, B A Effron

  • 1Division of Cardiology, University Hospitals of Cleveland, School of Medicine, Case Western Reserve University, Ohio 44106.

Annals of Emergency Medicine
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

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A 31-year-old woman died after an amoxapine overdose, experiencing prolonged QRS intervals and cardiac arrest. This case highlights the severe cardiotoxicity of amoxapine, even at lower lethal doses.

Area of Science:

  • Pharmacology
  • Toxicology
  • Cardiology

Background:

  • Tricyclic antidepressants (TCAs) are associated with cardiotoxicity.
  • Amoxapine is a TCA used for depression.
  • Limited data exists on amoxapine-induced cardiotoxicity, especially in overdose scenarios.

Observation:

  • A case report details a 31-year-old female patient with a 2-gram amoxapine overdose.
  • The patient exhibited significant QRS interval prolongation (>100 ms) throughout her hospitalization.
  • She experienced a bradycardic-hypotensive event, electromechanical dissociation, and ultimately died 33 hours post-admission.

Findings:

  • This acute ingestion represents the lowest reported lethal dose of amoxapine.
  • The prolonged QRS interval indicated significant cardiac conduction delay.

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  • The patient's death was attributed to cardiotoxicity secondary to the amoxapine overdose.

    • Implications:

    • This case underscores the critical risk of severe cardiotoxicity with amoxapine overdose.
    • It emphasizes the need for vigilant cardiac monitoring in patients with significant TCA ingestions.
    • Further research may be warranted to fully elucidate the cardiotoxic mechanisms of amoxapine.