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Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
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Cow's milk allergy prevention.

Elissa M Abrams1, Scott H Sicherer2

  • 1Section of Allergy and Clinical Immunology, Department of Pediatrics, University of Manitoba, Winnipeg, Canada; Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia, Vancouver, Canada.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|January 15, 2021
PubMed
Summary
This summary is machine-generated.

Early cow's milk introduction may prevent cow's milk allergy. Introducing cow's milk within the first month of life shows promise, potentially influenced by gut microbiome and vitamin D. Further research is needed.

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Area of Science:

  • Allergy and Immunology
  • Pediatric Medicine
  • Microbiome Research

Background:

  • Cow's milk allergy (CMA) is a significant concern in pediatrics.
  • Understanding prevention strategies is crucial for public health.

Purpose of the Study:

  • To conduct a scoping review on the prevention of IgE-mediated cow's milk allergy.
  • To synthesize current evidence on the role of early cow's milk ingestion.

Main Methods:

  • Comprehensive literature search of PubMed and gray literature.
  • Inclusion of peer-reviewed observational and randomized controlled studies.
  • Focus on the pediatric population and English-language publications.

Main Results:

  • Growing evidence supports early and ongoing cow's milk ingestion for CMA prevention.
  • Introduction within the first month of life is associated with a preventive role.
  • Potential mechanisms include gut colonization, microbial diversity, and vitamin D modulation.

Conclusions:

  • Further research is required to clarify optimal introduction timing and amounts.
  • Studies in high-risk populations are needed.
  • A consistent association exists between early cow's milk intake and allergy prevention.