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The Biological Roles of lncRNAs and Future Prospects in Clinical Application

Guohui Li1, Liang Deng1,2, Nan Huang2

  • 1School of Life Sciences, Jiangsu University, 301# Xuefu Road, Zhenjiang 212013, China.

Diseases (Basel, Switzerland)
|January 16, 2021
PubMed

Insights

Long noncoding RNAs (lncRNAs) are crucial in cellular responses to DNA damage. Their functions, regulated by N6-adenosine methylation (m6A), are vital for maintaining genomic stability and preventing cancer.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Chemotherapy and radiation induce DNA damage, leading to cell apoptosis.
  • DNA double-stranded breaks (DSBs) are a critical form of DNA damage.
  • Eukaryotic organisms possess complex DNA repair mechanisms to maintain genomic integrity.

Purpose of the Study:

  • To review the origin and functions of long noncoding RNAs (lncRNAs).
  • To highlight the involvement of lncRNAs in DNA damage response pathways.
  • To explore the regulatory role of N6-adenosine methylation (m6A) in lncRNA function.

Main Methods:

  • Literature review of studies on lncRNAs and DNA damage.
  • Analysis of lncRNA involvement in DNA repair mechanisms.
  • Examination of m6A modification's impact on lncRNA function in DNA damage response.

Main Results:

  • lncRNAs are significantly involved in cellular responses to DNA damage.
  • N6-adenosine methylation (m6A) dynamically regulates lncRNA roles in DNA repair.
  • Dysregulation of lncRNAs and their functions can contribute to tumorigenesis.

Conclusions:

  • lncRNAs are key players in the DNA damage response.
  • Understanding lncRNA regulation, including m6A modification, is crucial for cancer research.
  • lncRNAs' roles in gene expression and autophagy also link them to cancer development.
Keywords:
DNA damagecancergenomic integritylncRNArepair

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