Related Experiment Video
Updated: Nov 21, 2025

A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
Could Chronic Idiopatic Intestinal Pseudo-Obstruction Be Related to Viral Infections?
Emanuele Sinagra1,2, Gaia Pellegatta3, Marcello Maida4
1Gastroenterology and Endoscopy Unit, Fondazione Istituto San Raffaele-Giuseppe Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, Italy.
Abstract:
Chronic idiopathic intestinal pseudo-obstruction (CIIPO) is a disease characterized by symptoms and signs of small bowel obstruction in the absence of displayable mechanical obstruction. Due to the known neuropathic capacity of several viruses, and their localization in the intestine, it has been hypothesized that such viruses could be involved in the pathogenesis of CIIPO. The most frequently involved viruses are John Cunningham virus, Herpesviridae, Flaviviruses, Epstein-Barr virus and Citomegalovirus. Therefore, the present narrative review aims to sum up some new perspectives in the etiology and pathophysiology of CIIPO.
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