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Related Experiment Videos

Sequential nailfold capillary microscopy in scleroderma and related disorders.

M L Wong1, J Highton, D G Palmer

  • 1Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.

Annals of the Rheumatic Diseases
|January 1, 1988
PubMed
Summary

Nailfold capillary microscopy revealed progressive abnormalities in connective tissue diseases. Capillary enlargement appears to result from injury, preceding capillary loss in these conditions.

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Area of Science:

  • Rheumatology
  • Vascular Biology
  • Microscopy

Background:

  • Connective tissue diseases, including scleroderma, dermatomyositis, and mixed connective tissue disease, often exhibit nailfold capillary abnormalities.
  • Understanding the progression of these microvascular changes is crucial for disease management.

Purpose of the Study:

  • To investigate the sequential changes in nailfold capillaries over time in patients with various connective tissue diseases.
  • To determine the relationship between capillary enlargement, extravasation, and capillary loss.

Main Methods:

  • Monthly nailfold capillary microscopy was performed over seven months.
  • Seven patients with connective tissue diseases (scleroderma, dermatomyositis, mixed connective tissue disease, limited connective tissue disease) were included.

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Main Results:

  • Progressive enlargement of capillary loops was observed in several patients.
  • Capillary obliteration and the formation of avascular areas were noted.
  • Extravasation from capillaries typically occurred before capillary loss.

Conclusions:

  • Nailfold capillary abnormalities in these connective tissue diseases are progressive.
  • Capillary enlargement is likely a consequence of vascular injury, not a compensatory mechanism for loss.