Related Experiment Video

Updated: Nov 21, 2025

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Immune Functions of Signaling Lymphocytic Activation Molecule Family Molecules in Multiple Myeloma

Mariko Ishibashi1, Rimpei Morita1, Hideto Tamura2,3

  • 1Department of Microbiology and Immunology, Nippon Medical School, Tokyo 113-8602, Japan.

Cancers
|January 16, 2021
PubMed

The signaling lymphocytic activation molecule (SLAM) family receptors are expressed on various immune cells and malignant plasma cells in multiple myeloma (MM) patients. In immune cells, most SLAM family molecules bind to themselves to transmit co-stimulatory signals through the recruiting adaptor proteins SLAM-associated protein (SAP) or Ewing's sarcoma-associated transcript 2 (EAT-2), which target immunoreceptor tyrosine-based switch motifs in the cytoplasmic regions of the receptors. Notably, SLAMF2, SLAMF3, SLAMF6, and SLAMF7 are strongly and constitutively expressed on MM cells that do not express the adaptor proteins SAP and EAT-2. This review summarizes recent studies on the expression and biological functions of SLAM family receptors during the malignant progression of MM and the resulting preclinical and clinical research involving four SLAM family receptors. A better understanding of the relationship between SLAM family receptors and MM disease progression may lead to the development of novel immunotherapies for relapse prevention.

Keywords:
SLAM familySLAMF2 (CD48)SLAMF3 (CD229, Ly9)SLAMF6 (CD352, NTB-A)SLAMF7 (CD319, CRACC, CS1)immunotherapymultiple myeloma

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