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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

674
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Related Experiment Video

Updated: Nov 21, 2025

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
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Enteric Viruses and Inflammatory Bowel Disease.

Georges Tarris1,2, Alexis de Rougemont2, Maëva Charkaoui3

  • 1Department of Pathology, University Hospital of Dijon, F 21000 Dijon, France.

Viruses
|January 16, 2021
PubMed
Summary

Enteric viruses, including noroviruses and rotaviruses, may play a role in inflammatory bowel diseases (IBD) flare-ups. Further research is needed to understand these viral roles in IBD pathogenesis.

Keywords:
Crohn’s diseaseadenovirusaichi virusastrovirusinflammatory bowel diseasenorovirusrotavirussapovirusulcerative colitis

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Area of Science:

  • Gastroenterology
  • Virology
  • Immunology

Background:

  • Inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD), are complex multifactorial conditions.
  • The involvement of enteric viruses in IBD pathogenesis is not fully understood, particularly for common agents like noroviruses and rotaviruses.
  • Genetic factors, including polymorphisms in FUT2 and FUT3 genes affecting histo-blood group antigens, are linked to IBD and viral ligand presence.

Purpose of the Study:

  • To explore the potential role of enteric viruses in inflammatory bowel diseases (IBD).
  • To highlight the need for further investigation into viral contributions to IBD flare-ups and pathogenesis.

Main Methods:

  • Review of epidemiological studies and genome-wide association studies.
  • Examination of genetic associations between IBD, FUT2/FUT3 gene polymorphisms, and viral ligand expression.
  • Consideration of cellular mechanisms like autophagy and immune pathways (T-helper 1, T-helper 17) in response to viral infections.

Main Results:

  • Genome-wide association studies indicate a link between IBD, FUT gene polymorphisms, and intestinal ligands for noroviruses and rotaviruses.
  • Autophagy in Paneth cells and altered cytokine secretion in T-helper pathways are observed following enteric virus infections.
  • Interactions between enteric viruses and gut microbiota may influence IBD.

Conclusions:

  • Enteric viruses, including noroviruses and rotaviruses, are implicated in IBD pathogenesis.
  • Further research utilizing advanced techniques like human intestinal enteroids and multi-sampling is crucial to elucidate the precise role of enteric viruses in IBD.