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Updated: Nov 21, 2025
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
9.8K
Two-dimensional polynomial type canonical relaxation oscillator model for p53 dynamics
Gökhan Demirkıran1,2, Güleser Kalaycı Demir3, Cüneyt Güzeliş1
1Department of Electrical-Electronics Engineering, Yaşar University, Bornova, İzmir, 35100, Turkey.
IET Systems Biology
|January 16, 2021
Summary
The p53 network
Area of Science:
- Cellular Biology
- Systems Biology
- Biophysics
Background:
- The p53 network regulates the cellular DNA damage response.
- p53 exhibits distinct states (low, oscillation, high) linked to cell cycle progression, arrest, and apoptosis.
- Experimental studies implicate ATM and Wip1 interaction in p53 dynamics.
Purpose of the Study:
- To propose a mathematical model for p53 network dynamics.
- To investigate the roles of ATM and Wip1 in p53 network behaviors.
- To analyze mutations and suggest therapeutic strategies.
Main Methods:
- Developed a two-dimensional canonical relaxation oscillator model.
- Utilized mathematical analysis to study model behaviors.
- Simulated effects of parameter perturbations to model mutations.
Main Results:
- ATM and Wip1 interaction form the core mechanism of p53 dynamics.
- Wip1 degradation is a sensitive parameter, potentially linked to mutations.
- The model characterizes ATM deficiency and Wip1 overexpression.
Conclusions:
- The proposed model captures key p53 network behaviors.
- Wip1 is identified as a potential therapeutic target for p53-related mutations.
- Mathematical modeling provides insights into gene regulatory network dynamics.
Keywords:
ATM interactionDNA damage responseWip1 interactionataxia-telangiectasia mutated interactioncell apoptosiscell cycle arrestcellular biophysicsenzymesgene regulatory networkgeneticsmathematical analysismolecular biophysicsmolecular configurationsnormal cell cycle progressionp53 dynamicsp53 networktopological structuretwo-dimensional polynomial type canonical relaxation oscillator modelwild-type p53-induced phosphatase 1 interaction
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