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Updated: Nov 21, 2025

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
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Fontan-associated liver disease.

M J Parada Blázquez1, D Rodríguez Vargas2, J Mohigefer Barrera3

  • 1Unidad de Gestión Clínica de Radiodiagnóstico, Hospital Universitario Virgen del Rocío, Sevilla, España.

Radiologia
|January 16, 2021
PubMed
Summary
This summary is machine-generated.

Fontan-associated liver disease stems from altered blood flow after Fontan surgery, causing liver changes. Radiologists must recognize these liver manifestations and potential complications like cancer in Fontan patients.

Keywords:
Carcinoma hepatocelularCirugía de FontanEnfermedad hepática crónica asociada al FontanFibrosis hepáticaFocal nodular hyperplasia (FNH)-likeFontan surgeryFontan-associated liver diseaseHepatic fibrosisHepatocellular carcinomaHiperplasia nodular focal-like

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Area of Science:

  • Cardiology
  • Hepatology
  • Radiology

Background:

  • Fontan surgery corrects complex congenital heart defects but leads to chronic venous congestion.
  • This chronic congestion results in Fontan-associated liver disease (FALD), a progressive condition.

Purpose of the Study:

  • To review the pathophysiology of Fontan-associated liver disease.
  • To describe its histologic changes.
  • To outline its radiologic manifestations.

Main Methods:

  • Literature review focusing on pathophysiology, histology, and imaging findings of FALD.
  • Synthesis of data from relevant studies on Fontan circulation and liver sequelae.

Main Results:

  • FALD involves structural and functional liver changes due to Fontan surgery-induced hemodynamic alterations.
  • Histologic changes include fibrosis and cirrhosis.
  • Radiologic findings encompass altered liver size/shape, signal intensity changes, vascular abnormalities, and focal lesions.

Conclusions:

  • FALD is a direct consequence of Fontan surgery's hemodynamic effects.
  • Radiologic manifestations are diverse, including benign nodules and hepatocellular carcinoma.
  • Increased Fontan patient numbers necessitate radiologist familiarity with FALD and its imaging surveillance.