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Related Experiment Video

Updated: Nov 21, 2025

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

Published on: April 1, 2022

Operative risks of the Ross procedure.

Paul Stelzer¹, Javier Mejia¹, Robin Varghese¹

¹Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York, NY.

The Journal of Thoracic and Cardiovascular Surgery

|January 16, 2021

Summary

The Ross procedure demonstrates excellent outcomes, even in complex cases involving reoperative surgery. This study confirms its safety and efficacy across a broad patient range.

Keywords:

Ross procedure aortic root replacement pulmonary autograft

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Area of Science:

Cardiovascular Surgery
Thoracic Surgery
Surgical Outcomes

Background:

The safety and effectiveness of the Ross procedure remain subjects of ongoing discussion.
This study evaluates immediate outcomes in a large cohort, including complex cases.

Purpose of the Study:

To assess the immediate outcomes of the Ross procedure.
To analyze results in patients undergoing reoperative and/or concomitant cardiac procedures.

Main Methods:

A consecutive cohort of 702 patients undergoing the Ross procedure between 1987 and 2019.
Patients were stratified into simple (no prior sternotomy, minor concomitant procedures) and complex (prior sternotomy and/or complex concomitant procedures) groups.
Outcomes were analyzed over time, with increasing complexity in cases.

Main Results:

Overall operative mortality was 1% (7 deaths), with 6.6% morbidity (46 patients).
The simple Ross group had 0.7% mortality and 4.8% morbidity.
The complex Ross group showed 1.4% mortality and 9.2% morbidity, with an increase in complex cases over time.

Conclusions:

The Ross procedure yields excellent results.
Broader indications, including reoperative sternotomy and concomitant procedures, are well-tolerated.
The procedure is a safe and effective option for a wide spectrum of patients.