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A new autoantibody in patients with rheumatoid arthritis: characterization of the anti-HaT-1 antibody system
1Department of Internal Medicine, School of Medicine, Fujita-Gakuen Health University, Aichi, Japan.
Abstract:
A unique, new autoantibody, anti-HaT-1, has been identified in the serum of patients with rheumatoid arthritis (RA). Anti-HaT-1 antibody is predominantly IgM, and reacts by double immunodiffusion with HaT-1 antigen, an acidic protein in human and rat liver supernatant (MW approximately 150,000). It was detected in 9 of 38 patients with RA, 2 of 15 patients with RA and Sjögren's syndrome, and none of 92 patients with other connective tissue diseases, indicating that this autoantibody is highly specific for RA.
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