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Aluminum-related bone disease.

H H Malluche1, M C Faugere

  • 1Department of Medicine, University of Kentucky, Lexington.

Blood Purification
|January 1, 1988
PubMed
Summary

Aluminum accumulation in patients with kidney failure causes bone disease. This review examines aluminum metabolism, toxicity, and its relationship with other minerals and hormones in bone health.

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Area of Science:

  • Biochemistry
  • Nephrology
  • Pathology

Background:

  • Aluminum, the most abundant metal, is increasingly recognized for its biological and pathogenetic significance.
  • Accumulations of aluminum have been observed in various organs, including the brain, kidneys, and bone, prompting research into its absorption, toxicity, and metabolism.
  • The kidney's role as the primary excretory organ for aluminum highlights the potential for its accumulation in patients with renal failure.

Purpose of the Study:

  • To investigate abnormalities in bone associated with aluminum accumulation in patients with renal failure.
  • To determine the metabolic interrelationships between aluminum, parathyroid hormone, vitamin D, iron, and calcium in the context of renal failure.
  • To provide an overview of recent investigations into aluminum accumulation and its effects on bone disease.

Main Methods:

  • Review of recent investigations on aluminum accumulation in humans and experimental animal models.
  • Analysis of cellular-level studies on aluminum metabolism.
  • Examination of documented studies on metabolic relationships involving aluminum.

Main Results:

  • Aluminum accumulation in bone is a significant issue in patients with renal failure.
  • Complex metabolic interrelationships exist between aluminum, parathyroid hormone, vitamin D, iron, and calcium.
  • Aluminum-related bone disease presents diagnostic challenges and requires specific approaches for prevention and therapy.

Conclusions:

  • Aluminum accumulation in bone is a critical concern in patients with impaired kidney function.
  • Understanding the intricate metabolic pathways is essential for managing aluminum-related bone disease.
  • Further research is needed to fully elucidate and address the complexities of aluminum-related bone disease.

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