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Epidemiology of Hospitalized Intussusception Cases from Northern States in India
Madhu Gupta1, Ravi Kanojia2, Adarsh Bansal3
1Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. madhugupta21@gmail.com.
Insights
Rotavirus vaccination is associated with intussusception in infants. This study describes the epidemiology of intussusception in India following vaccine introduction, providing data for safety assessments.
Area of Science:
- Pediatric Gastroenterology
- Vaccinology
- Public Health Surveillance
Background:
- Intussusception is a significant cause of intestinal obstruction in infants.
- The introduction of rotavirus vaccines necessitates ongoing surveillance for potential adverse events, including intussusception.
Purpose of the Study:
- To describe the epidemiology of intussusception following the introduction of the rotavirus vaccine in northern India.
- To provide data for assessing the impact and safety of rotavirus vaccination.
Main Methods:
- A hospital-based active surveillance system was implemented in three tertiary care hospitals.
- Children under two years of age admitted with intussusception were enrolled according to Brighton Collaboration Level-I criteria.
- Clinical characteristics, treatment, seasonal trends, and outcomes were documented.
Main Results:
- A total of 224 intussusception cases were reported.
- The majority of cases involved males (71%) and infants (69.5%).
- Intussusception cases peaked in the summer, with ileo-colic location in 85% and requiring conservative treatment in 54% and surgery in 46%.
Conclusions:
- Surveillance data offer an epidemiological profile of intussusception post-rotavirus vaccine introduction in northern India.
- These findings are crucial for evaluating vaccine impact and safety, particularly concerning intussusception.
Objective:
To describe epidemiology of intussusception post-introduction of the rotavirus vaccine.
Methods:
Hospital-based active surveillance system was set up in three tertiary care hospitals in Chandigarh and Haryana, India, to enroll children <2 y of age admitted with intussusception as per Brighton Collaboration Level-I criteria. The clinical characteristics, treatment modalities, seasonal trends, and outcome of the illness episodes were described.
Results:
A total of 224 cases were reported. Majority were males (71%) and infants (69.5%). Number of intussusception was more in summer season. Location of intussusception was ileo-colic in 85% of the cases. Nearly 54% cases were treated conservatively and 46% needed surgical intervention.
Conclusion:
Surveillance data provided the epidemiological description of intussusception cases post-introduction of the rotavirus vaccine in northern India. This data could be used to assess the impact of vaccine and safety with a special focus on intussusception.
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