The FeNO Normal Value Analysis of Healthy Children Aged 6-15 Years Old in Chengdu
Tao Ai1, Ronghua Luo2, Lei Zhang2
1Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 1617, Section 1, Riyue Avenue, Qingyang District, Chengdu City, Sichuan Province, China. ait1108@163.com.
Insights
The upper limit for fractional exhaled nitric oxide (FeNO) in healthy children aged 6-15 is 28.0 ppb. Values above this suggest potential airway inflammation and should consider age, height, and weight.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
Background:
- Fractional exhaled nitric oxide (FeNO) is a biomarker for airway inflammation.
- Establishing normal FeNO values in pediatric populations is crucial for accurate diagnosis.
Purpose of the Study:
- To determine the normal upper limit value of FeNO in healthy children aged 6-15 years.
- To provide a basis for clinical diagnosis of airway inflammation in children.
Main Methods:
- FeNO levels were measured in 481 healthy children (aged 6-15) from primary schools in Chengdu.
- Statistical analysis was performed to determine the upper limit of normal FeNO and analyze influencing factors.
Main Results:
- The geometric mean FeNO value was 14.59 ppb (range: 5-69 ppb).
- The upper limit of normal FeNO was established at 28.0 ppb.
- Age, height, and weight showed significant correlations with FeNO levels.
Conclusions:
- The normal upper limit for FeNO in healthy children aged 6-15 years is 28.0 ppb.
- FeNO values exceeding 28.0 ppb may indicate airway inflammation.
- Factors including age, weight, and height must be considered when interpreting FeNO results in children.
Objective:
To investigate the fractional exhaled nitric oxide (FeNO) normal value of healthy children, and provide a reliable theoretical basis for clinical diagnosis.
Methods:
481 healthy children aged 6-15-y-old in three primary schools in Chengdu were subjected for FeNO detection. Through the statistical analysis, the upper limit normal value of FeNO among the healthy children was obtained, and the related influencing factors of FeNO value were analyzed.
Results:
Among the 481 heathy children, the geometric mean value of FeNO was 14.59 ppb (minimum value was 5 ppb, maximum value was 69 ppb), and the upper limit of normal value was 28 ppb. The age, height, and weight all have significant correlations with FeNO.
Conclusion:
The upper limit of FeNO in healthy children aged 6-15-y-old was 28.0 ppb. Inflammation in the airway was suggested when the value of FeNO exceeds 28.0 ppb. Furthermore, the influencing factors such as age, weight, height must be considered.
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