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Bone Disease in CKD in Children.
Fernando Santos1,2, Lucas Díaz-Anadón3, Flor A Ordóñez3
1Division of Pediatric Nephrology, Hospital, Universitario Central de Asturias, Avda de Roma s/n, 33011, Oviedo, Asturias, Spain. fsantos@uniovi.es.
Calcified Tissue International
|January 16, 2021
Summary
Mineral and bone disorders in chronic kidney disease (MBD-CKD) impede growth in pediatric patients. This review covers MBD-CKD pathophysiology, growth retardation, and strategies for prevention and treatment.
Area of Science:
- Pediatric Nephrology
- Endocrinology
- Skeletal Biology
Background:
- Mineral and bone disorders (MBD-CKD) are a significant complication in children with chronic kidney disease.
- These disorders can lead to severe growth retardation and skeletal abnormalities.
Purpose of the Study:
- To provide a comprehensive overview of MBD-CKD in pediatric populations.
- To detail the pathophysiology, clinical manifestations, and impact on growth.
- To outline current and future strategies for management.
Main Methods:
- Literature review focusing on MBD-CKD in pediatric chronic kidney disease.
- Analysis of studies on growth plate alterations and their relation to MBD-CKD.
- Synthesis of evidence regarding therapeutic and preventive interventions.
Main Results:
- MBD-CKD involves complex biochemical and hormonal alterations affecting bone metabolism.
- Growth retardation in MBD-CKD is multifactorial, involving hormonal imbalances and direct effects on the growth plate.
- Current treatments aim to normalize mineral metabolism and support growth, but optimal strategies are still evolving.
Conclusions:
- Effective management of MBD-CKD is crucial for optimizing growth outcomes in pediatric patients.
- A multidisciplinary approach is necessary for addressing the complexities of MBD-CKD.
- Further research is needed to refine prevention and treatment strategies for MBD-CKD in children.
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