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Bone Disease in CKD in Children.

Fernando Santos1,2, Lucas Díaz-Anadón3, Flor A Ordóñez3

  • 1Division of Pediatric Nephrology, Hospital, Universitario Central de Asturias, Avda de Roma s/n, 33011, Oviedo, Asturias, Spain. fsantos@uniovi.es.

Calcified Tissue International
|January 16, 2021
PubMed
Summary

Mineral and bone disorders in chronic kidney disease (MBD-CKD) impede growth in pediatric patients. This review covers MBD-CKD pathophysiology, growth retardation, and strategies for prevention and treatment.

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Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Skeletal Biology

Background:

  • Mineral and bone disorders (MBD-CKD) are a significant complication in children with chronic kidney disease.
  • These disorders can lead to severe growth retardation and skeletal abnormalities.

Purpose of the Study:

  • To provide a comprehensive overview of MBD-CKD in pediatric populations.
  • To detail the pathophysiology, clinical manifestations, and impact on growth.
  • To outline current and future strategies for management.

Main Methods:

  • Literature review focusing on MBD-CKD in pediatric chronic kidney disease.
  • Analysis of studies on growth plate alterations and their relation to MBD-CKD.
  • Synthesis of evidence regarding therapeutic and preventive interventions.

Main Results:

  • MBD-CKD involves complex biochemical and hormonal alterations affecting bone metabolism.
  • Growth retardation in MBD-CKD is multifactorial, involving hormonal imbalances and direct effects on the growth plate.
  • Current treatments aim to normalize mineral metabolism and support growth, but optimal strategies are still evolving.

Conclusions:

  • Effective management of MBD-CKD is crucial for optimizing growth outcomes in pediatric patients.
  • A multidisciplinary approach is necessary for addressing the complexities of MBD-CKD.
  • Further research is needed to refine prevention and treatment strategies for MBD-CKD in children.