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Generation of Alginate Microspheres for Biomedical Applications

Generation of Alginate Microspheres for Biomedical Applications

Published on: August 12, 2012

Starch modified alginate nanoparticles for drug delivery application.

Deepa Thomas¹, Neethu Mathew¹, Megha S Nath¹

¹Research and Post Graduate Department of Chemistry, Bishop Moore College, Maveleikara, Kerala, India.

International Journal of Biological Macromolecules

|January 16, 2021

Summary

We developed novel starch-modified alginate nanoparticles for drug delivery. These biocompatible nanoparticles show pH-dependent release and good encapsulation efficiency, making them promising for controlled drug delivery applications.

Keywords:

Alginate Bovine serum albumin Drug delivery Starch Theophylline

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Area of Science:

Biomaterials Science
Nanotechnology
Drug Delivery Systems

Background:

Natural polymers are extensively researched for drug and bioactive molecule encapsulation and delivery.
Alginate and starch are biocompatible natural polymers with potential in developing drug delivery vehicles.

Purpose of the Study:

To develop starch-modified alginate nanoparticles using a green, facile technique for drug delivery.
To evaluate the encapsulation efficiency, pH-dependent drug release, biocompatibility, and cellular uptake of the developed nanoparticles.

Main Methods:

Starch-modified alginate nanoparticles were synthesized via a green, facile method.
Theophylline and bovine serum albumin were used as model drugs for encapsulation studies.
In vitro drug release, cytotoxicity assays (L929 fibroblast cell line), and cellular uptake studies (fluorescent microscopy) were performed.

Main Results:

The nanoparticles achieved an encapsulation efficiency ranging from 60% to 75%.
In vitro drug release studies demonstrated pH-dependent release characteristics.
Cytotoxicity tests confirmed the biocompatibility of the nanoparticles with L929 fibroblast cell lines.
In vitro cellular uptake was successfully visualized in L929 fibroblast cells.

Conclusions:

Starch-modified alginate nanoparticles are effectively prepared using a green and facile technique.
The developed nanoparticles exhibit promising characteristics for controlled drug delivery, including good encapsulation and pH-dependent release.
The biocompatibility and cellular uptake potential suggest these nanoparticles are suitable candidates for future drug delivery applications.