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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
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Retinal nonperfusion in optical coherence tomography angiography
Limin Liu1, Fan Xia2, Rui Hua1
1Department of Ophthalmology, First Hospital of China Medical University, Shenyang, China.
Photodiagnosis and Photodynamic Therapy
|January 16, 2021
Summary
Optical coherence tomography angiography (OCTA) can show retinal nonperfusion (NP), but other conditions mimic these signals. Understanding these mimics is crucial for accurate diagnosis and treatment of retinal diseases like diabetic retinopathy.
Area of Science:
- Ophthalmology
- Medical Imaging
Background:
- Retinal nonperfusion (NP) is a key indicator for diabetic retinopathy and retinal vein occlusion severity.
- Optical coherence tomography angiography (OCTA) can detect NP, but other conditions may present similar flow void signals.
Purpose of the Study:
- To review mechanisms causing false NP signals in OCTA.
- To compare OCTA and fluorescein angiography for NP evaluation.
- To improve understanding of NP detection in retinal diseases.
Main Methods:
- Literature review of OCTA findings.
- Analysis of discrepancies between OCTA and fluorescein angiography.
- Evaluation of signal morphology and size.
Main Results:
- Vascular occlusion causes true NP, appearing as flow voids in OCTA.
- Cystoid macular edema can displace vessels, creating false NP signals in OCTA.
- Multiple pathologies can coexist, complicating NP interpretation.
Conclusions:
- Accurate interpretation of OCTA requires differentiating true NP from artifacts.
- Understanding mimics of NP in OCTA aids in appropriate diagnostic and treatment strategies.
- Distinguishing true from false NP signals is vital for managing retinal vascular diseases.
